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Clinical Evidence Fractured Neck of Femur

Clinical evidence for the use of COPAL® G+C, a high-dose dual antibiotic-loaded bone cement, for prosthesis fixation after fractured neck of femur.

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Prosthetic Arthroplasty in Fractured Neck of Femur

Proximal fractures of the neck of femur (FNOF) are typical injuries within the elderly.1,2,3 Immediate restoration of weight-bearing capacity and prevention of complications – particularly of surgical site infection (SSI) – are very important. Cemented hemiarthroplasty represents a good surgical treatment option, particularly for patients with reduced mobility, cognition and/or reduced life expectancy.4
Application of a dual antibiotic-loaded bone cement (DALBC) such as COPAL® G+C can lower the risk of periprosthetic joint infection and its sequelae in vulnerable patients effectively.4

Sprowson et al. Bone Joint J 2016

The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip: The fractured hip infection trial

 

Prospective, double-blinded, quasi-randomised trial in 848 patients with cemented hemiarthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. single antibiotic-loaded bone cement (SALBC).

Click to see study details

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Tyas et al. J Bone Joint Infect 2018

Antibiotic resistance profiles of deep surgical site infections in hip hemiarthroplasty; comparing low dose single antibiotic versus high dose dual antibiotic impregnated cement

 

Retrospective analysis in 1,941 patients with cemented hemiarthroplasty due to hip fracture: infection rates and antibiotic resistance following the use of COPAL® G+C vs. SALBC.

Click to see study details

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Savage et al. Ann R Coll Surg Engl 2019

Arthroplasty infection rates in fractured neck of femur: single vs dual antibiotic cement

 

Retrospective and prospective non-randomised analysis in 206 patients with cemented (hemi-)arthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. SALBC.

Click to see study details

 

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Agni et al. Lancet 2023

High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trial

 

Prospective, multicentre, randomised, controlled trial (WHiTE 8) in 4,936 patients following cemented hemiarthroplasty due to FNOF: infection rates following the use of COPAL® G+C vs. SALBC.

Click to see study details

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