Clinical Evidence

High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trial

Agni NR, Costa ML, Achten J, Peckham N, Dutton SJ, Png ME, Reed MR for the WHiTE 8 Investigators
Lancet 2023; 402: 196-202.

At a glance

Overall rate of deep surgical site infection (SSI) was 1.5% at 90 days of follow-up
- Deep SSI rate of 1.2% when protheses were cemented with COPAL^® G+C vs. 1.7% deep SSI rate when protheses were fixed with low-dose single antibiotic-loaded bone cement (SALBC)
No differences with respect to secondary outcomes

Study details

Prospective randomised multicentre study in patients aged 60 years and older with cemented hemiarthroplasty after fractured neck of femur (FNOF)
Comparison of prothesis fixation with high-dose dual antibiotic-loaded bone cement (DALBC) COPAL^® G+C vs. SALBC
Primary endpoint: deep SSI at 90 days post-randomisation

Study Design: Randomised trial in 4,936 patients aged 60 years and older with cemented hemiarthroplasty after FNOF. Control group: 2,453 patients randomised to SALBC; intervention group: 2,483 patients randomised to COPAL G+C. Primary endpoint was deep SSI at 90 days post-randomisation. Figure based on Agni et al. (2023)

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High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomized controlled trial

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