Clinical Evidence

Arthroplasty infection rates in fractured neck of femur: single vs dual antibiotic cement

Savage P, McCormick M, Al-Dadah O
Ann R Coll Surg Engl 2019; 101: 514–518.

At a Glance

No deep surgical site infections (SSI) were observed when prostheses had been cemented with COPAL^®G+C vs. 2.8% deep SSI when prostheses were fixed with low-dose single antibiotic-loaded bone cement (SALBC) at 12 months of follow-up
Superficial SSI rate of 5.1% in the COPAL^® G+C group vs. 3.7% in the SALBC group at 12 months of follow-up

Study details

Retrospective and prospective analysis of 206 patients with cemented (hemi-)arthroplasty after fractured neck of femur (FNOF)
Comparison of prothesis fixation with high-dose dual antibiotic-loaded bone cement (DALBC) COPAL^® G+C vs. SALBC
Endpoints: deep and superficial SSI within 12 months following surgery

Study Design: Analysis of 206 patients with cemented (hemi-)arthroplasty after FNOF: including 108 retrospective patients fixed with SALBC and 98 prospective patients fixed with COPAL G+C. Primary endpoint was deep SSI at 12 month after surgery. Figure based on Savage et al. (2019)

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Arthroplasty infection rates in fractured neck of femur: single vs dual antibiotic cement

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