Clinical Evidence
The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasty for the treatment of a fracture of the hip:
The fractured hip infection trial
Sprowson AP, Jensen C, Chambers S, Parson NR, Aradhyula NM, Carluke I, Inman D, Reed MR
Bone Joint J. 2016; 98-B: 1534-1541.
At a Glance
- Significant reduction in the rates of deep as well as of deep and superficial surgical site infections (SSI) within 12 months following prosthesis fixation with COPAL® G+C vs. low-dose single antibiotic-loaded bone cement (SALBC)
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Deep SSI rate of 1.1% in the COPAL® G+C group vs. 3.5% in the SALBC group
- Deep and superficial SSI rate of 1.7% in COPAL® G+C group vs. 5.3% in the SALBC group
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- Complications did not differ between the two groups
Study Details
- Prospective, double-blinded, quasi-randomised controlled study in patients with cemented hemiarthroplasty after fractured neck of femur (FNOF)
- Comparison of prosthesis fixation with high-dose dual antibiotic-loaded bone cement (DALBC) COPAL® G+C vs. SALBC
- Primary endpoint: deep SSI within 12 months following surgery
